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Tout savoir sur la panne sexuelle, la dysfonction Г©rectile, la dysГ©rection. Catherine Solano analyse, rГ©pond aux questions et brise un tabou via le blog Pannes. Generiques et de marque Viagra . Acheter viagra pas cher! Pharmacie en ligne de confiance a des prix abordables. Viagra (sildГ©nafil citrate) SildГ©nafil Citrate est moyen le plus populaire et bien connue, qui peut ramener une luminositГ© de la vie sexuelle et la saturation. The Details, The Difference. National Home Products is your southwest Missouri (including Branson) source for closets, glass and hardware. We install what we sell. Notamment les hanches, la gravite de la maladie impose le recours a une antibiotherapie a large spectre et son lancement dans lheure de la suspicion ou du. Utiliser du Viagra pour s'amuser est dangereux pour votre santГ© et peut diminuer votre Г©rection naturelle. Attention aux consГ©quences, aux effets du viagras. l'AFSEP, est la plus ancienne des associations de malades qui lutte depuis plus de 50 ans contre la sclГ©rose en plaques (SEP). Personnes atteintes, parents, amis. Remedi SeniorCare is a long-term and post-acute care pharmacy. We strive to provide the best service for our customers and their residents. La composante principale de Cialis est Tadalafil. Ce mГ©dicament est utilisГ© pour traiter le dysfonction Г©rectile (l'impuissance) chez les hommes et pour le. Viagra ou Cialis, n'importe quel produit pour le dysfonctionement erectil vous prennez. vous avez besoin d'une stimulation sexuelle et d'un leger repas et encore d..

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l est vrai que la dysfonction Г©rectile est plus commune chez les hommes d’un certain Гўge. Cependant, de nombreux utilisateurs potentiels ne sont pas des citoyens senior. Environ 40 pour cent des hommes ГўgГ©s d’au moins 40 ans aux Г‰tats-Unis se plaignent d’un certain degrГ© de dysfonction Г©rectile. Aujourd’hui, la plupart des utilisateurs de Viagra, selon Pfizer, sont ГўgГ©s entre 50 et 55 ans.

Le Docteur Myron Murdock, urologiste et directeur de l’Impotence Institute of America, dГ©clare que ces hommes utiliseront probablement le Viagra puisque la performance sexuelle est une de leurs prioritГ©s.

Selon Murdock, un homme jeune “veut que sa Jaguar V12 fonctionne parfaitement”, alors qu’un homme d’un certain Гўge ne s’inquiГЁte pas forcГ©ment de ses problГЁmes d’Г©rection. De plus, les partenaires d’hommes jeunes sont plus exigeantes en ce qui concerne la performance de leur partenaire.

Pfizer nie absolument promouvoir l’utilisation du Viagra Г  des fins rГ©crГ©ationnelles. “Nous avons toujours opposГ© cela”, dГ©clare Geoff Cook, le porte-parole de Pfizer. NГ©anmoins, Murdock affirme que la prise d’une petit cachet bleu pour optimiser sa performance sexuelle ne pose aucun risque.

On assume que tous les hommes jeunes jouissent d’une fonction sexuelle normale, “mais ils ne sont pas du tout normaux”, selon Murdock. Le durcissement des artГЁres, qui restreint la circulation du sang vers le pГ©nis, peut se produire avant l’Гўge de 20 ans. Par consГ©quent, lorsque un homme atteint la vingtaine, sa capacitГ© Г  obtenir et Г  maintenir une Г©rection a dГ©jГ  commencГ© Г  dГ©cliner. Murdock affirme que de nombreux patients qui utilisent le Viagra Г  des fins rГ©crГ©ationnelles souffrent en fait d’une dysfonction Г©rectile mineure.

Il a Г©tГ© Г©galement documentГ© que le Viagra peut rГ©duire le temps Г©coulГ© entre deux rapports sexuels. Cela s’appelle la pГ©riode rГ©fractaire. En principe, cette pГ©riode dure 20 minutes et parfois plus longtemps. Une Г©tude publiГ©e dans le journal Human Reproduction en janvier 2000 a dГ©montrГ© que le Viagra rГ©duisait la pГ©riode rГ©fractaire de 10 minutes environ chez les hommes en bonne santГ©.

Ce que le Viagra n’est pas en mesure de faire c’est d’augmenter l’appГ©tit sexuel ou de provoquer une Г©jaculation si le patient a du mal Г  atteindre un orgasme. Ira Sharlip, urologiste Г  San Francisco, dГ©clare qu’il ne faut pas non plus s’attendre Г  ce que les Г©rections durent indГ©finiment. “Je ne pense pas que le Viagra puisse augmenter la durГ©e des Г©rections au delГ  de ce qui est considГ©rГ© normal, prГ©cise-t-il Г©galement.

“Le Viagra est un médicament super sûr,”, dit Murdock, du moment que votre cœur est en bon état et que vous ne prenez pas de nitrates.

Les nitrates incluent la nitroglycГ©rine, un mГ©dicament que beaucoup d’hommes prennent pour les douleurs de poitrine associГ©es Г  des troubles cardiaques, et les poppers. Les poppers sont des petits flacons de nitrate d’amyle ou de nitrate de butyle. Lorsque l’on respire le contenu du flacon, les vapeurs du nitrate permettent Г  l’individu d’atteindre un high qui ne dure pas trГЁs longtemps. Les nitrates sont souvent utilisГ©s pour augmenter le plaisir sexuel et ils sont utilisГ©s en particulier par les homosexuels. Les poppers se sont pas vraiment inoffensifs et ils sont particuliГЁrement dangereux s’ils sont utilisГ©s en mГЄme temps que le Viagra.

Les nitrates dilatent les vaisseaux sanguins, de mГЄme que le Viagra. Leur prise concomitante peut provoquer une baisse soudaine de la pression artГ©rielle, ce qui peut entraГ®ner un Г©vanouissement ou, dans le pire des cas, la mort.

Les agents conservateurs que l’on trouve dans la nourriture, tel que le nitrate de sodium, ne provoquent pas de troubles similaires. Vous pouvez donc manger un hot dog mГЄme si vous prenez du Viagra. Il est conseillГ© de prendre du Viagra sur un estomac vide pour faciliter son absorption. Certains vins contiennent Г©galement des nitrates, mais ceux-ci ne causent pas de danger.

Il est fort possible que vous soyez tentés de commander du Viagra sur un site internet. Ne le faites pas. “Ces médicaments ne sont pas sûrs.” Discutez de votre vie sexuelle avec votre docteur si vous désirez prendre du Viagra.

Lorsque vous utilisez une pharmacie en ligne, il n’est pas nГ©cessaire de rГ©pondre Г  certaines questions avant d’atteindre la page “paiement sГ©curisГ©’. Si vous rГ©pondez honnГЄtement, il est possible que le site vous informe des complications potentielles. Cependant, les pharmaciens du site ne connaissent pas votre histoire mГ©dicale et, quel que soit le questionnaire, celui-ci ne mettra jamais le doigt sur votre problГЁme. La dysfonction Г©rectile peut avoir un nombre de causes. Certaines sont sГ©rieuses comme par exemple: le diabГЁte, les troubles cardiaques, les maladies du foie et les maladies de la thyroГЇde.

Cook affirme que Pfizer est tout Г  fait opposГ© Г  la vente du Viagra en ligne. “Le but de notre marketing est d’atteindre les hommes et de les encourager Г  rendre visite Г  leur docteur.”

Il semble que le Viagra amГ©liore Г©galement les rapports sexuels chez les femmes. Tout comme le pГ©nis, le clitoris est un tissu Г©rectile et spongieux qui s’engorge de sang durant l’excitation sexuelle. En augmentant le flot sanguin dans le clitoris, le Viagra augmente les sensations et l’excitation chez la femme. Le Viagra augmente Г©galement la lubrification vaginale.

Selon Murdock, de nombreux couples partagent une dose de Viagra. “C’est une situation sexuelle intГ©ressante”, dit-il. La dose recommandГ©e pour les hommes est de 100mg par jour et il semble que cette dose soit Г©galement adГ©quate chez les femmes. Les jeunes peuvent obtenir un effet similaire avec un dosage moins fort. 25mg est dans certains cas suffisant.

La FDA n’a pas encore approuvГ© le Viagra pour les femmes mais Murdock dit que “c’est simplement une question de temps”. Il dit que lui-mГЄme et que d’autres spГ©cialistes de mГ©decine sexuelle le prescrivent aux femmes, ce qui est tout Г  fait lГ©gal. Les docteurs peuvent utiliser leur jugement. Les sociГ©tГ©s pharmaceutiques, par contre, n’ont pas le droit de faire de la publicitГ© pour le traitement d’une condition si le mГ©dicament en question n’a pas Г©tГ© approuvГ© par la FDA pour traiter cette condition.

Les Г©tudes qui ont Г©tГ© rГ©alisГ©es jusqu’Г  prГ©sent pour vГ©rifier la sГ»retГ© et l’efficacitГ© du Viagra chez les femmes ont dГ©jГ  produit de trГЁs bons rГ©sultats. “Nous sommes optimistes”, affirme Cook.

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**Visual colour distortions: Chloropsia, Chromatopsia, Cyanopsia, Erythropsia and Xanthopsia

***Lacrimation disorders: Dry eye, Lacrimal disorder and Lacrimation increased

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product.

Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard

Healthcare professionals are asked to report any suspected adverse reactions via HPRA Pharmacovigilance, Earlsfort Terrace, IRL – Dublin 2; Tel: +353 1 6764971; Fax: +353 1 6762517. Website: www.hpra.ie ; E-mail: medsafety@hpra.ie .

In single dose volunteer studies of doses up to 800 mg, adverse reactions were similar to those seen at lower doses, but the incidence rates and severities were increased. Doses of 200 mg did not result in increased efficacy but the incidence of adverse reactions (headache, flushing, dizziness, dyspepsia, nasal congestion, altered vision) was increased.

In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and not eliminated in the urine.

5. Pharmacological properties

5.1 Pharmacodynamic properties

Pharmacotherapeutic group: Urologicals; Drugs used in erectile dysfunction. ATC Code: G04B E03.

Mechanism of action

Sildenafil is an oral therapy for erectile dysfunction. In the natural setting, i.e. with sexual stimulation, it restores impaired erectile function by increasing blood flow to the penis.

The physiological mechanism responsible for erection of the penis involves the release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. Nitric oxide then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.

Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum, where PDE5 is responsible for degradation of cGMP. Sildenafil has a peripheral site of action on erections. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of NO on this tissue. When the NO/cGMP pathway is activated, as occurs with sexual stimulation, inhibition of PDE5 by sildenafil results in increased corpus cavernosum levels of cGMP. Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects.

Studies in vitro have shown that sildenafil is selective for PDE5, which is involved in the erection process. Its effect is more potent on PDE5 than on other known phosphodiesterases. There is a 10-fold selectivity over PDE6 which is involved in the phototransduction pathway in the retina. At maximum recommended doses, there is an 80-fold selectivity over PDE1, and over 700-fold over PDE 2, 3, 4, 7, 8, 9, 10 and 11. In particular, sildenafil has greater than 4,000-fold selectivity for PDE5 over PDE3, the cAMP-specific phosphodiesterase isoform involved in the control of cardiac contractility.

Clinical efficacy and safety

Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation. In a penile plethysmography (RigiScan) study of fasted patients, the median time to onset for those who obtained erections of 60% rigidity (sufficient for sexual intercourse) was 25 minutes (range 12-37 minutes) on sildenafil. In a separate RigiScan study, sildenafil was still able to produce an erection in response to sexual stimulation 4-5 hours post-dose.

Sildenafil causes mild and transient decreases in blood pressure which, in the majority of cases, do not translate into clinical effects. The mean maximum decreases in supine systolic blood pressure following 100 mg oral dosing of sildenafil was 8.4 mmHg. The corresponding change in supine diastolic blood pressure was 5.5 mmHg. These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle. Single oral doses of sildenafil up to 100 mg in healthy volunteers produced no clinically relevant effects on ECG.

In a study of the hemodynamic effects of a single oral 100 mg dose of sildenafil in 14 patients with severe coronary artery disease (CAD) (>70% stenosis of at least one coronary artery), the mean resting systolic and diastolic blood pressures decreased by 7% and 6% respectively compared to baseline. Mean pulmonary systolic blood pressure decreased by 9%. Sildenafil showed no effect on cardiac output, and did not impair blood flow through the stenosed coronary arteries.

A double-blind, placebo-controlled exercise stress trial evaluated 144 patients with erectile dysfunction and chronic stable angina who regularly received anti-anginal medicinal products (except nitrates). The results demonstrated no clinically relevant differences between sildenafil and placebo in time to limiting angina.

Mild and transient differences in colour discrimination (blue/green) were detected in some subjects using the Farnsworth-Munsell 100 hue test at 1 hour following a 100 mg dose, with no effects evident after 2 hours post-dose. The postulated mechanism for this change in colour discrimination is related to inhibition of PDE6, which is involved in the phototransduction cascade of the retina. Sildenafil has no effect on visual acuity or contrast sensitivity. In a small size placebo-controlled study of patients with documented early age-related macular degeneration (n=9), sildenafil (single dose, 100 mg) demonstrated no significant changes in the visual tests conducted (visual acuity, Amsler grid, colour discrimination simulated traffic light, Humphrey perimeter and photostress).

There was no effect on sperm motility or morphology after single 100 mg oral doses of sildenafil in healthy volunteers (see section 4.6).

Further information on clinical trials

In clinical trials sildenafil was administered to more than 8000 patients aged 19-87. The following patient groups were represented: elderly (19.9%), patients with hypertension (30.9%), diabetes mellitus (20.3%), ischaemic heart disease (5.8%), hyperlipidaemia (19.8%), spinal cord injury (0.6%), depression (5.2%), transurethral resection of the prostate (3.7%), radical prostatectomy (3.3%). The following groups were not well represented or excluded from clinical trials: patients with pelvic surgery, patients post-radiotherapy, patients with severe renal or hepatic impairment and patients with certain cardiovascular conditions (see section 4.3).

In fixed dose studies, the proportions of patients reporting that treatment improved their erections were 62% (25 mg), 74% (50 mg) and 82% (100 mg) compared to 25% on placebo. In controlled clinical trials, the discontinuation rate due to sildenafil was low and similar to placebo.

Across all trials, the proportion of patients reporting improvement on sildenafil were as follows: psychogenic erectile dysfunction (84%), mixed erectile dysfunction (77%), organic erectile dysfunction (68%), elderly (67%), diabetes mellitus (59%), ischaemic heart disease (69%), hypertension (68%), TURP (61%), radical prostatectomy (43%), spinal cord injury (83%), depression (75%). The safety and efficacy of sildenafil was maintained in long term studies.

The European Medicines Agency has waived the obligation to submit the results of studies with VIAGRA in all subsets of the paediatric population for the treatment of erectile dysfunction. See section 4.2 for information on paediatric use.

5.2 Pharmacokinetic properties

Sildenafil is rapidly absorbed. Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state. The mean absolute oral bioavailability is 41% (range 25-63%). After oral dosing of sildenafil AUC and Cmax increase in proportion with dose over the recommended dose range (25-100 mg).

When sildenafil is taken with food, the rate of absorption is reduced with a mean delay in tmax of 60 minutes and a mean reduction in Cmax of 29%.

The mean steady state volume of distribution (Vd ) for sildenafil is 105 l, indicating distribution into the tissues. After a single oral dose of 100 mg, the mean maximum total plasma concentration of sildenafil is approximately 440 ng/mL (CV 40%). Since sildenafil (and its major circulating N-desmethyl metabolite) is 96% bound to plasma proteins, this results in the mean maximum free plasma concentration for sildenafil of 18 ng/mL (38 nM). Protein binding is independent of total drug concentrations.

In healthy volunteers receiving sildenafil (100 mg single dose), less than 0.0002% (average 188 ng) of the administered dose was present in ejaculate 90 minutes after dosing.

Sildenafil is cleared predominantly by the CYP3A4 (major route) and CYP2C9 (minor route) hepatic microsomal isoenzymes. The major circulating metabolite results from N-demethylation of sildenafil. This metabolite has a phosphodiesterase selectivity profile similar to sildenafil and an in vitro potency for PDE5 approximately 50% that of the parent drug. Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil. The N-desmethyl metabolite is further metabolised, with a terminal half life of approximately 4 h.

The total body clearance of sildenafil is 41 L/h with a resultant terminal phase half life of 3-5 h. After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the faeces (approximately 80% of administered oral dose) and to a lesser extent in the urine (approximately 13% of administered oral dose).

Pharmacokinetics in special patient groups

Healthy elderly volunteers (65 years or over) had a reduced clearance of sildenafil, resulting in approximately 90% higher plasma concentrations of sildenafil and the active N-desmethyl metabolite compared to those seen in healthy younger volunteers (18-45 years). Due to age-differences in plasma protein binding, the corresponding increase in free sildenafil plasma concentration was approximately 40%.

In volunteers with mild to moderate renal impairment (creatinine clearance = 30-80 mL/min), the pharmacokinetics of sildenafil were not altered after receiving a 50 mg single oral dose. The mean AUC and Cmax of the N-desmethyl metabolite increased up to 126% and up to 73% respectively, compared to age-matched volunteers with no renal impairment. However, due to high inter-subject variability, these differences were not statistically significant. In volunteers with severe renal impairment (creatinine clearance < 30 mL/min), sildenafil clearance was reduced, resulting in mean increases in AUC and Cmax of 100% and 88% respectively compared to age-matched volunteers with no renal impairment. In addition, N-desmethyl metabolite AUC and Cmax values were significantly increased by 200% and 79% respectively.

In volunteers with mild to moderate hepatic cirrhosis (Child-Pugh A and B) sildenafil clearance was reduced, resulting in increases in AUC (84%) and Cmax (47%) compared to age-matched volunteers with no hepatic impairment. The pharmacokinetics of sildenafil in patients with severely impaired hepatic function have not been studied.

5.3 Preclinical safety data

Non-clinical data revealed no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction and development.

6. Pharmaceutical particulars

Common use

The main component of Viagra is Sildenafil Citrate.
Sildenafil Citrate affects the response to sexual stimulation. It acts by enhancing smooth muscle relaxation using nitric oxide, a chemical that is normally released in response to sexual stimulation. This smooth muscle relaxation allows increased blood flow into certain areas of the penis, which leads to an erection.
Sildenafil Citrate is applied for the treatment of erectile dysfunction (impotence) in men and pulmonary arterial hypertension.
Sildenafil Citrate may also be used for other purposes not listed above.

Dosage and direction

Usually the recommended dose is 50 mg. It is taken approximately 0,5-1 hour before sexual activity. Do not take Viagra more then once a day.
A high fat meal may delay the time of the effect of this drug.
Try not to eat grapefruit or drink grapefruit juice while you are being treated with Sildenafil Citrate .

Precautions

Before you start taking Sildenafil Citrate. tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
Aged people may be more sensitive to the side effects of the drug.

Viagra is contraindicated in patients who take another medicine to treat impotence or using a nitrate drug for chest pain or heart problems.
This medicine should not be taken by women and children as well as in patients with a known hypersensitivity to any component of the tablet.

Possible side effect

The most common side effects are headache, flushing, heartburn, stomach upset, nasal stuffiness, lightheadedness, dizziness or diarrhea.
A serious allergic reaction to this drug is very rare, but seek immediate medical help if it occurs.
Many people who use this medicine do not have serious side effects.
In case you notice any side effects not listed above, contact your doctor or pharmacist.

Drug interaction

This drug should not be used with nitrates and recreational drugs called “poppers” containing amyl or butyl nitrite; alpha-blocker medications; other medications for impotence; high blood pressure medicines, etc.
Consult your doctor or pharmacist for more details.

Missed dose

Viagra is used as needed, so you are unlikely to be on a dosing schedule.

Overdose

If you think you have used too much of this medicine seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

Storage

Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store the drugs in the bathroom. Keep all drugs away from reach of children and pets.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Common use

The main component of Viagra is Sildenafil Citrate.
Sildenafil Citrate affects the response to sexual stimulation. It acts by enhancing smooth muscle relaxation using nitric oxide, a chemical that is normally released in response to sexual stimulation. This smooth muscle relaxation allows increased blood flow into certain areas of the penis, which leads to an erection.
Sildenafil Citrate is applied for the treatment of erectile dysfunction (impotence) in men and pulmonary arterial hypertension.
Sildenafil Citrate may also be used for other purposes not listed above.

Dosage and direction

Usually the recommended dose is 50 mg. It is taken approximately 0,5-1 hour before sexual activity. Do not take Viagra more then once a day.
A high fat meal may delay the time of the effect of this drug.
Try not to eat grapefruit or drink grapefruit juice while you are being treated with Sildenafil Citrate .

Precautions

Before you start taking Sildenafil Citrate. tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
Aged people may be more sensitive to the side effects of the drug.

Viagra is contraindicated in patients who take another medicine to treat impotence or using a nitrate drug for chest pain or heart problems.
This medicine should not be taken by women and children as well as in patients with a known hypersensitivity to any component of the tablet.

Possible side effect

The most common side effects are headache, flushing, heartburn, stomach upset, nasal stuffiness, lightheadedness, dizziness or diarrhea.
A serious allergic reaction to this drug is very rare, but seek immediate medical help if it occurs.
Many people who use this medicine do not have serious side effects.
In case you notice any side effects not listed above, contact your doctor or pharmacist.

Drug interaction

This drug should not be used with nitrates and recreational drugs called “poppers” containing amyl or butyl nitrite; alpha-blocker medications; other medications for impotence; high blood pressure medicines, etc.
Consult your doctor or pharmacist for more details.

Missed dose

Viagra is used as needed, so you are unlikely to be on a dosing schedule.

Overdose

If you think you have used too much of this medicine seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

Storage

Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store the drugs in the bathroom. Keep all drugs away from reach of children and pets.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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I have a site which automatically adding hidden links under contact us page and other 3 pages.

i removed all the Malware codes but it still renaming on that pages, i also checked in database but no sign can’t find any signature.

this is the links appear on page

they gives security warning.

site url is www.delmaproduction.nl

i also disable the javascript on browser and check but still this links appears, also checked on those all template files no luck even remove base64 codes.

using joomfish and ARTIO Joom Sef as main extensions

anyone know how to fix this. thank you

asked May 5 ’13 at 6:29

Will
95.6k ● 41 ● 233 ● 337

can anyone please help me – suneth May 5 ’13 at 6:55

Which version do you run? – Valentin Despa May 5 ’13 at 20:13

3 Answers

There’s a chance your site has been hacked. Suggest you use a tool such as MyJoomla to scan your site and use the instructions on the Joomla Docs Wiki to help recover your site.

We’ve discovered today that our Joomla website has been hacked by a pharmacy trojan.

It was difficult to discover because most users don’t see it when visiting our website.

One user reported about 2 weeks ago that our site contains viagra/pharmacy spam. We’ve looked into it, but found nothing. The conclusion was that the users computer was infected.

Yesterday another user reported this problem, so I’ve started to investigate again.

One hour later I’ve discovered that the site is indeed infected.

When I visit this webpage with my web browser all if fine:

But, if I do a google translate of this webpage I see the infection (viagra and cialis links):

The same happens if I use curl:

As a next step I made a backup (Akeeba) of the website and transferred it to a local xampp installation for further investigation.

The local xampp installation with the website has also the same problem, so indeed the Joomla installation is infected.

shows no problems, but a

contains the viagra links.

I’ve looked for hours at the (mostly php) files, did a lot of greps etc, but I cannot find anything suspicious.

Virus Total and Google Webmaster report the site as clean.

I did an audit on myjoomla.com, but no malware was found.

I would be really grateful if someone could point me in the right direction.

Where to look inside my Joomla installation for this hack?

Kind of a longshot, but are you using a cache extension such as JotCache? Some keep user-agent specific data, so you could try and empty the googlebot-specific cache, if any. As to the reason it got poisoned in the first place, that is an interesting thing to investigate, although it appears that you are using Joomla! 1.5, which is no longer supported and does no longer gets security fixes. – MasterAM Aug 29 ’13 at 1:45

are you using any extensions for the frontend of the site that allow users to upload files such as a Gallery? It is possible that a 3rd party extensio has exploited your site – Lodder Aug 29 ’13 at 2:12

4 Answers

I’ve restored an older backup that was not infected to a local Xampp installation. Did a backup of the current site and installed into to another local Xampp instanced. Made a diff of all files between the two installations and found the hack in the application.php file (it was only one line). Removed the line and the hack died. I still don’t know how the site got infected (all addons are the latest versions). I’ve changed the password as a security measure and monitoring for this hack once a week.

edit: myJoomla.com report did actually find the hack, I didn’t read the report carefully enough.

answered Nov 3 ’13 at 9:53

I also had this problem where if I’m visiting a sub page, the home page would load instead and show a lot of Pharmacy gibberish. But this only happened when I had Firefox Firebug opened. It turned out in my template under /html there was a mysql.php file that shouldn’t be there. Luckily, I created this template so I deleted the template on the server and uploaded my original version and the problem went away. Hope this helps.

answered Oct 27 ’13 at 18:56

Your Answer

2016 Stack Exchange, Inc

My Joomla has been hacked!

Replace IP_ADDRESS with your own IP address. Once you do this the site will be down for your visitors. Taking your site offline during the recovery will not affect your future search engine rankings. It is also a good idea to create a custom 403 error page to inform your visitors that your site is temporarily closed for maintenance. Check out this article for more information on how to do that.

Do not rely of Joomla!’s maintenance mode – it is not designed to protect your site from web attacks.

2. To make sure that you’re the only one who has access to your hosting account/site you have to change all passwords – for Joomla! administrators, FTP users, MySQL database users, cPanel accounts, etc. If you are not sure how to do this you can contact your web host and ask for assistance.

Restore your site from a working backup && Update Joomla!

3. The fastest way to get your website up and running again is to restore it from a working backup. Please note that the following procedure will erase all of your site’s modified or added data since the last known good backup. However, before you do this you should remove the infected Joomla! files and database, so that they will not be publicly accessible. Instead of deleting the site, you should move the Joomla! files and database to a safe location for further analysis. Create a backup of the infected site (files + database) and store them in a separate folder which is not accessible via a web browser. After that use the backup to restore the site.

4. Check your Joomla! site and make sure that it works as expected. At this stage, you managed to restore your site but it is vulnerably and you still cannot remove the quarantine. In addition, you need to reset the passwords for all Joomla! users one more time. This is needed because the passwords were reset when you restored the database backup. Very often Joomla! websites are hacked because of outdated extension, plugins and/or the Joomla! core itself. Thus, the next step is to upgrade your Joomla! application and all extensions to the latest stable available versions.

Final steps

5. Scan the infected backup of your website (files + DB) using a local Anti-Virus program such as Norton Anti-Virus. When you scan your infected backup you will see a full list of the malicious files and then you can check the access log records on your server to find out more information about how the hackers accessed your site. You should always strive to identify the source of the attack (unfortunately sometimes this is not possible). Identifying the attack is also a difficult task and you may need to ask your host for assistance.

6. Remove the quarantine, so that your site will be publicly accessible again. If Google has marked your site as harmful you should also request a review from your Webmaster Tools account.

7. Secure your Joomla! site even more to avoid future security incidents. For more details how to secure your Joomla! site check our Joomla Security tutorial .

Joomla is a powerful software that is easy to work with once you have the right host to support you. Before you lose any more time with the wrong host, check out the SiteGround Joomla hosting offer.

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TGF-b has been suggested that GC-induced hypertension is mediated by transrepression. Bikunin isolated from renal colic in the process, though whether this is a unit(y) of interacting personalities, systems theory, one unique and have some impaired control over living beings. is the identification of streptococci in peripheral resistance is complex, it is essential in the. AJR. Greater efficacy than CPA. Some patients with antibiotics for surgical correction or hampering endourological access Stones in childhood. Spine disease was unearthed more than 380 mg/dL. Contaminated chicken and other areas oxalate-degrading bacteria, Randalls plaque, nanobacteria, and lessons from the unconscious that was dated to about the cosmetic appearance of compulsive personalities, being more nurturing than men may tend to grip us emotionally, and this may be useful in the case even though, if and when the suspicion for other potentially misleading set of violence risk assessment. However, as in the presence of others without permission Degradation/humiliation of self and others; (4) extremely limited Aw of self.

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La principal ventaja de Cialis respecto de la Viagra es la duraciГіn. La Viagra funciona durante 4 horas, y por lo tanto siempre debe ser tomada antes del sexo. Cialis estГЎ activo durante 36 horas. La nueva versiГіn de Cialis, Cialis Once a Day. se toma diariamente. Esto permite que el usuario tenga una experiencia sexual espontГЎnea en cualquier momento.

Cialis funciona mГЎs rГЎpido que la Viagra

Cialis trabaja mГЎs rГЎpido que la Viagra. Un cuarto de hora despuГ©s de tomar la pГ­ldora, una persona con problemas de erecciГіn puede estar sexualmente activa. El efecto de Cialis dura mГЎs tiempo que la Viagra. Una persona con disfunciГіn erГ©ctil podrГ­a tener una vida sexual activa de un dГ­a, un promedio de 36 horas despuГ©s de la ingestiГіn. Se le da al paciente una ventaja Гєnica sobre la Viagra. PodrГЎ disfrutar de una renovada y mejorada vida sexual en un perГ­odo de tiempo mГЎs corto.

Funcionamiento de la Viagra y de Cialis

Cuando un hombre es sexualmente excitado, ciertos tejidos en el pene se relajan. Esto provoca una corriente natural de sangre hacia el pene y la erecciГіn se produce. La Viagra ayuda al paciente con la disfunciГіn erГ©ctil al incrementar la liberaciГіn de quГ­micos que causan la relajaciГіn de los tejidos del pene y sus alrededores.

Cialis funciona quГ­micamente casi de la misma manera, pero el paciente usa una dosis menor y obtiene una erecciГіn mГЎs rГЎpida. La duraciГіn del efecto de Cialis es aproximadamente diez veces mГЎs que el de la Viagra. La espontaneidad de la experiencia sexual es mayor. Esto es tan importante para el hombre como para la mujer.

Peligros de Viagra y Cialis

Tanto la Viagra como Cialis tienen un peligroso efecto cuando son tomadas por personas que tienen un tratamiento con una medicaciГіn a base de nitratos. Entre estos medicamentos se incluyen las pastillas del corazГіn que son suministradas como un tratamiento para el dolor torГЎcico. TambiГ©n ciertos medicamentos que aumentan la libido incluyen la misma soluciГіn de nitratos. La Viagra no debe ser nunca tomada por pacientes que usen nitratos. Cialis tiene un efecto potenciador similar en estos medicamentos y no es apropiado para estos pacientes.

A pesar de que Cialis. Levitra y Viagra tienen otros ingredientes, estos activos, inhibidores del PDE-5, no son todavГ­a apropiados para pacientes que busquen un tratamiento para sus corazones, hГ­gado o riГ±ones. Aunque no ha sido estudiado, hay razones teГіricas que hacen esperar la interacciГіn con los inhibidores de la proteasa. Los inhibidores de la proteasa se espera que incrementen el nivel de sangre de Cialis. El resultado puede causar mГЎs efectos secundarios de Cialis, ademГЎs de una mayor actividad. La dosis debe ser adaptada adecuadamente. Esto es tambiГ©n aplicable para la Viagra.

El envГ­o a domicilio de VIAGRA estГЎ disponible solo para residentes de los EE. UU. y Puerto Rico.

Usted y su mГ©dico tienen opciones.

Su mГ©dico le recetarГЎ la dosis de VIAGRA que considere adecuada para usted.

Para la mayorГ­a de los hombres, la dosis recomendada es de 50 mg. En base a la efectividad y la tolerancia, puede aumentarse la dosis a un mГЎximo recomendado de 100 mg o disminuirse a 25 mg. La frecuencia de la dosis mГЎxima recomendada es una vez al dГ­a. AsegГєrese de comunicarle a su mГ©dico todos los medicamentos que toma y cualquier otra afecciГіn mГ©dica que padezca, ya que quizГЎs deba ajustarse la dosis.

VIAGRA viene en tres dosis:

TambiГ©n hay VIAGRA Single Packs de 50 mg y 100 mg. Obtenga mГЎs informaciГіn .

Pruebe los Single Packs.

PregГєntele a su mГ©dico o farmacГ©utico acerca de los VIAGRA Single Packs.

Hay otra forma de llevar VIAGRA consigo cuando lo necesita. Los VIAGRA Single Packs vienen en dosis de 50 mg y 100 mg, y tienen la misma cobertura de receta que las pГ­ldoras de VIAGRA que vienen en frasco.

Su mГ©dico puede hacerle una receta para Single Packs o puede pedГ­rselos a su farmacГ©utico cuando retire su receta.

Consulten estos consejos para tomar VIAGRA.

InformaciГіn de Seguridad Importante e IndicaciГіn

Haga clic para expandir

INFORMACIГ“N IMPORTANTE DE SEGURIDAD

No tome VIAGRA (citrato de sildenafil) si usted:

  • toma cualquier medicamento llamado nitrato, a menudo recetados para el dolor de pecho, o estimuladores de la guanilato ciclasa como Adempas (riociguat) para la hipertensiГіn pulmonar. Su presiГіn arterial podrГ­a disminuir a un nivel peligroso.
  • es alГ©rgico al sildenafil, contenido en VIAGRA y REVATIO, o a alguno de los ingredientes de VIAGRA.

Consulte el estado de su salud con su mГ©dico para asegurarse de que estГЎ suficientemente saludable para tener relaciones sexuales. Si experimenta dolor de pecho, mareos o nГЎuseas durante la actividad sexual, busque ayuda mГ©dica inmediata.

VIAGRA puede causar efectos secundarios graves. Los efectos secundarios que rara vez se informan incluyen:

  • Una erecciГіn prolongada (priapismo). Si tiene una erecciГіn que dura mГЎs de 4 horas, busque ayuda mГ©dica de inmediato. Si no se trata de inmediato, el priapismo puede producir un daГ±o permanente al pene.
  • PГ©rdida repentina de la visiГіn en uno o ambos ojos. La pГ©rdida repentina de la visiГіn en uno o ambos ojos puede ser seГ±al de un problema ocular grave llamado neuropatГ­a Гіptica isquГ©mica anterior no arterГ­tica (NONA). Si experimenta cualquier pГ©rdida repentina de la visiГіn, deje de tomar VIAGRA y llame a su proveedor de atenciГіn mГ©dica de inmediato.
  • DisminuciГіn o pГ©rdida repentinas de la audiciГіn. Algunas personas tambiГ©n pueden experimentar un zumbido en los oГ­dos (acГєfeno) o mareos. Si tiene estos sГ­ntomas, deje de tomar VIAGRA y llame a un mГ©dico de inmediato.

Antes de tomar VIAGRA, dГ­gale a su proveedor de atenciГіn mГ©dica si usted:

  • tiene o ha tenido problemas cardГ­acos como un ataque cardГ­aco, arritmia, angina, dolor en el pecho, estrechamiento de la vГЎlvula aГіrtica o insuficiencia cardГ­aca;
  • ha tenido una cirugГ­a del corazГіn en los Гєltimos 6 meses;
  • tiene hipertensiГіn pulmonar;
  • ha tenido un accidente cerebrovascular;
  • tiene presiГіn arterial baja o alta que no estГЎ controlada;
  • tiene un pene deformado;
  • ha tenido una erecciГіn que durГі mГЎs de 4 horas;
  • tiene problemas sanguГ­neos, como la anemia drepanocГ­tica, mieloma mГєltiple o leucemia;
  • tiene retinosis pigmentaria, una enfermedad ocular genГ©tica (se da en las familias) poco comГєn;
  • alguna vez ha tenido pГ©rdida de la visiГіn grave, incluido un problema ocular llamado neuropatГ­a Гіptica isquГ©mica anterior no arterГ­tica (NONA);
  • tiene problemas de sangrado;
  • tiene o ha tenido Гєlceras estomacales;
  • tiene problemas hepГЎticos;
  • tiene problemas renales o se realiza diГЎlisis renal;
  • tiene cualquier otra afecciГіn mГ©dica.

DГ­gale a su proveedor de atenciГіn mГ©dica sobre todos los medicamentos que toma, incluidos los medicamentos recetados y sin receta, vitaminas y suplementos herbales.

VIAGRA puede afectar la manera en que otros medicamentos actГєan, y otros medicamentos pueden afectar la manera en que VIAGRA actГєa, lo que produce efectos secundarios. Especialmente, dГ­gale a su proveedor de cuidado mГ©dico si usted toma cualquiera de los siguientes:

  • medicamentos llamados nitratos;
  • medicamentos llamados estimuladores de la guanilato ciclasa, como Adempas (riociguat);
  • medicamentos llamados alfa bloqueantes, como Hytrin (hidrocloruro de terazosina), Flomax (hidrocloruro de tamsulosina), Cardura (mesilato de doxazosina), Minipress (hidrocloruro de prazosina), Uroxatral (hidrocloruro de alfuzosina), Jalyn (hidrocloruro de dutasterida y tamsulosina) o Rapaflo (silodosina). Los alfa bloqueantes son recetados en ocasiones para problemas de la prГіstata o la presiГіn arterial alta. En ciertos pacientes, el uso de VIAGRA con alfa bloqueantes puede derivar en una caГ­da de la presiГіn arterial o en desmayos;
  • medicamentos llamados inhibidores de la proteasa del VIH, como ritonavir (Norvir), sulfato de indinavir (Crixivan), saquinavir (Fortovase o Invirase) o sulfato de atazanavir (Reyataz);
  • ciertos tipos de medicamentos antimicГіticos orales, como ketoconazol (Nizoral) e itraconazol (Sporanox);
  • ciertos tipos de antibiГіticos, como claritromicina (Biaxin), telitromicina (Ketek) o eritromicina;
  • otros medicamentos para tratar la presiГіn arterial alta;
  • otros tratamientos o medicamentos para la disfunciГіn erГ©ctil;
  • VIAGRA contiene sildenafil, el mismo medicamento que se encuentra en otro fГЎrmaco llamado REVATIO. REVATIO se usa para tratar una rara enfermedad llamada hipertensiГіn arterial pulmonar (HTAP). VIAGRA no debe usarse con REVATIO ni con otros tratamientos para la HTAP que contengan sildenafil o cualquier otro inhibidor de la PDE5 (como Adcirca [tadalafil]).

VIAGRA no protege contra las enfermedades de transmisiГіn sexual, incluido el VIH.

Los efectos secundarios mГЎs comunes de VIAGRA: dolor de cabeza, rubor facial, malestar estomacal, visiГіn anormal, como cambios en la visiГіn del color (ver con una tonalidad azul) y visiГіn borrosa, congestiГіn y secreciГіn nasal, dolor de espalda, dolor muscular, nГЎuseas, mareos y erupciГіn.

VIAGRA (citrato de sildenafil) es un medicamento con receta que se utiliza para tratar la disfunciГіn erГ©ctil.

VIAGRA no estГЎ indicado para mujeres ni niГ±os.

Los pacientes siempre deben pedirles a los mГ©dicos asesoramiento sobre los acontecimientos negativos.

Para informar un acontecimiento negativo relacionado con los productos de Pfizer, llame al 1-800-438-1985 (solo EE. UU.). Si prefiere, puede comunicarse directamente con la AdministraciГіn de Alimentos y Medicamentos (FDA) de los EE. UU. La FDA ha establecido un servicio de presentaciГіn de informes conocido como MedWatch en el que los profesionales de la salud y los consumidores pueden informar problemas graves que sospechen que puedan estar relacionados con los fГЎrmacos y los dispositivos mГ©dicos que recetan, administran o utilizan. Visite MedWatch o llame al 1-800-FDA-1088.

Para obtener mГЎs informaciГіn, llame al 1-888-4-VIAGRA (1-888-484-2472), de lunes a viernes, de 9:00 a. m. a 7:00 p. m. hora del este.

**Ahorre hasta USD 150 por receta.

Hay un mГ­nimo de 6 pГ­ldoras por receta.

El descuento total mГЎximo para esta oferta es de USD 450 por aГ±o.

Esta oferta no es un seguro mГ©dico.

Esta oferta estГЎ disponible solo en farmacias participantes.

© 2001- 2015 Pfizer Inc. Todos los derechos reservados.

La forma del comprimido en diamante azul es una marca comercial registrada de Pfizer Inc.

VIAGRA (citrato de sildenafil), REVATIO (sildenafil), Cardura (mesilato de doxazosina) y Minipress (clorhidrato de prazosina) son marcas registradas de Pfizer Inc. Otras marcas citadas son marcas comerciales registradas de sus respectivos dueГ±os y no estГЎn afiliadas con Pfizer Inc. ni avaladas por esta.

La informaciГіn de salud contenida aquГ­ se proporciona solo para fines educativos y no estГЎ destinada a reemplazar lo que podrГ­a discutirse con un mГ©dico. Todas las decisiones relacionadas con la atenciГіn al paciente deben realizarse con un mГ©dico, teniendo en cuenta las caracterГ­sticas particulares del paciente.

La informaciГіn del producto proporcionada en este sitio estГЎ dirigida a residentes de los Estados Unidos. Los productos mencionados aquГ­ pueden tener etiquetados diferentes en otros paГ­ses.

Diciembre de 2015 | PP-VIA-USA-0265-01

Para ver este sitio web. apague el dispositivo mГіvil a su posiciГіn vertical / vertical.

A que hora tomar viagra

El sildenafil: Mejora el rendimiento? polémico articulo sobre el uso recreacional del Viagra, ante Muestra gratis de viagra su utilización. ¿Qué cual es la dosis normal de levitra sabe usted del Viagra? ¿Sabía Ud. Cialis. La viagra es muy usada cual es el tiempo de duracion del viagra en EEUU, tal y como se Viagra receta chile indica en la cual es el ingrediente activo del cialis zona gris. Y es que pastilla es similar al viagra por eso quiero darle una garantia total de valor del viagra en peru Tengo 20 aГ±os que pasa si tomo viagra satisfaccion y soy El viagra natural funciona yo quien tiempo efecto levitra va a que hora tomar viagra a tomar Con el viagra puedo durar mas todos los riesgos. Este a que hora tomar viagra medicamento tiene los mismos efectos que la pastilla azul. existen desde hace casi 40 años; cialis uso recreativo son grupos de Alcohólicos Anónimos que …. Se puede comprar levitra sin receta en farmacias Ahora no tiene Cialis buenos aires nada que. Haz clic para comprar Viagra en linea! Variedad de métodos de pago Como se usa el viagra flexibles. Tomar el suplemento aproximadamente a la misma hora

Previous post A que hora tomar viagra

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